Publications
Group highlights
QUILT2 is a scalable, read-aware genotype imputation method that uses biobank-scale reference panels. It accurately imputes genotypes from short reads, long reads, linked reads and ancient DNA, and introduces a mode for jointly imputing maternal and fetal genomes from non-invasive prenatal testing data.
Li, Z.; Albrechtsen, A.; Davies, R.W.
Nature Communications 17, 524 (2026)
We analyzed genetic and plasma proteomics data from 3,707 Greenlandic individuals and identified 251 primary protein quantitative trait loci, including 70 novel associations. Arctic-enriched variants affecting protein abundance provided new insights into cardiometabolic disease in Greenland.
Stinson, S.E.; Balboa, R.F.; Andersen, M.K.; Stæger, F.F.; He, S.; Thuesen, A.C.B.; Lin, L.; Jørsboe, E.; Bjerregaard, P.; Larsen, C.V.L.; Grarup, N.; Jørgensen, M.E.; Moltke, I.; Albrechtsen, A.📨; Hansen, T.📨
The American Journal of Human Genetics 112(12), 2982-2994 (2025)
SVUPP achieved higher accuracy than cuteSV2, Sniffles2 and kanpig with both long and ultra long Oxford Nanopore Technologies (ONT) data as well as Pacific Biosciences (PacBio) HiFi data for genotyping SVs without close neighbor SVs.
Li, Z.📨, Stæger, F.F., Davies, R.W., Moltke, I.📨, & Albrechtsen, A📨.
The saola is one of the most elusive large mammals, standing at the brink of extinction. We constructed a reference genome and resequenced 26 saola individuals.
Garcia-Erill, G., Liu, S., Le, M.D., Hurley, M.M., Nguyen, H.D., Nguyen, D.Q., Nguyen, D.H., Santander, C.G., Sánchez Barreiro, F., Gomes Martins, N.F., Hanghøj, K., Salleh, F.M., Ramos-Madrigal, J., Wang, X., Sinding, M.S., Morales, H.E., Stæger, F.F., Wilkinson, N., Meng, G., Pečnerová, P., Yang, C., Rasmussen, M.S., Schubert, M., Dunn, R.R., Moltke, I., Zhang, G., Chen, L., Wang, W., Cao, T.T., Nguyen, H.M., Siegismund, H.R., Albrechtsen, A.📨, Gilbert, M.T.📨, & Heller, R.📨
Current Biology comment
Popular articles discover magazine, BBC wildlife, Earth.com,Die Spiegel, ekstrabladet (danish)
We show that lack of representation of Inuit in genetic research leads to inequity in healthcare opportunities by inclusion of Greenlandic genetic data we can greatly improve the diagnose novel genetic diseases.
Stæger F.F.; Andersen M.K.; Li Z.; Hjerresen J.P.; He S.; Santander C.G.; Jensen R.T.; Rex K.F.; Thuesen A.C.B.; Hanghøj K.; Seiding I.H.; Jørsboe E.; Stinson S.E.; Rasmussen M.S.; Balboa R.F.; Larsen C.V.L.; Bjerregaard P.; Schubert M.; Meisner J.; Linneberg A.; Grarup N.; Zeggini E.; Nielsen R.; Jørgensen M.E.; Hansen T.📨; Moltke I.📨; Albrechtsen A.📨
Nature News and News and Views
Popular articles phys.org, El Pais, Videnskab.dk in Danish, El HuffPost, focus.it
We show that population structure affect LD, pruning and clumping. We derive at new measure of LD that is corrected for population structure and admixture which improved downstream analysis
Ulises Bercovich, Malthe Sebro Rasmussen, Zilong Li, Carsten Wiuf, Anders Albrechtsen
Genetics, (2025) Pdf on my website
software for admixture aware LD, pruning and clumping PCAone
We what that the Impala is highly structured despite being the posterchild of a species is Stasis.
Garcia-Erill G.; Wang X.; Rasmussen M.; Quinn L.; Khan A.; Bertola L.; Santander C.; Balboa R.; Ogutu J.; Pečnerová P.; Hanghøj K.; Kuja J.; Nursyifa C.; Masembe C.; Muwanika V.; Bibi F.; Moltke I.; Siegismund H.; Albrechtsen A.📨; Heller R.📨
Sibling-based analysis separates genetic and environmental effects, showing ancestry-related differences in mean genetic values for metabolic traits between Inuit and Europeans.
Long Lin, Mette K. Andersen, Frederik Filip Stæger, Zilong Li, Kristian Hanghøj, Allan Linneberg, Niels Grarup, Marit Eika Jørgensen, Torben Hansen📨, Ida Moltke📨 & Anders Albrechtsen📨
Genomic analyses show how historical introgression and modern barriers to migration have shaped diversity and genetic connectivity among wildebeest populations.
Xiaodong Liu* , Long Lin* , Mikkel-Holger S. Sinding* , Laura D. Bertola, Kristian Hanghøj, Liam Quinn, Genís Garcia-Erill, Malthe Sebro Rasmussen, Mikkel Schubert, Patrícia Pečnerová, Renzo F. Balboa, Zilong Li, Michael P. Heaton, Timothy P. L. Smith, Rui Resende Pinto, Xi Wang, Josiah Kuja, Anna Brüniche-Olsen, Jonas Meisner, Cindy G. Santander, Joseph O. Ogutu, Charles Masembe, Rute R. da Fonseca, Vincent Muwanika, Hans R. Siegismund, Anders Albrechtsen📨, Ida Moltke📨, Rasmus Heller📨
Nature Communications 15, 2921 (2024)
Twitter Thread Laura Bertola
news The consersation, earth.com, Danish new Politiken
Whole-genome analyses reveal that ancient admixture played a major role in forming present-day giraffe lineages and their complex evolutionary relationships.
Laura D. Bertola* , Liam Quinn* , Kristian Hanghøj* , Genís Garcia-Erill, Malthe Sebro Rasmussen, Renzo F. Balboa, Jonas Meisner, Thomas Bøggild, Xi Wang, Long Lin, Casia Nursyifa, Xiaodong Liu, Zilong Li, Mumbi Chege, Yoshan Moodley, Anna Brüniche-Olsen, Josiah Kuja, Mikkel Schubert, Morris Agaba, Cindy G. Santander, Mikkel-Holger S. Sinding, Vincent Muwanika, Charles Masembe, Hans R. Siegismund, Ida Moltke 📨 , Anders Albrechtsen 📨, Rasmus Heller 📨,
Twitter Thread Laura Bertola
We shed light on the evolutionary history of an iconic and widespread African mammal and provide insight into the longstanding biogeographic puzzle surrounding the bushpig’s presence in Madagascar
Balboa* , Bertola* , Brüniche-Olsen* , … Moltke 📨, Albrechtsen 📨, Heller 📨;
Nature Communications 15, 172 (2024)
Popular articles bnn breaking, DR news in Danish Le Monde in French
How to infer the ancestry of an admixed individuals pedigree.
Genís Garcia-Erill📨, Kristian Hanghøj, Rasmus Heller, Carsten Wiuf, Anders Albrechtsen
When do distances in a PCA reflex genetic ancestry? if two individuals cluster togeather does that mean they are some the same populations? Here we present a method that you can use to interpret you genetic PCA plot.
Jan van Waaij* 📨, Song Li* , Genís Garcia-Erill* , Anders Albrechtsen, Carsten Wiuf📨;
A method for accurate PCA for large scale genetic data. Analyse millions of sites for all 500000 individuals in UKbiobank on your labtop
Zilong Li📨, Jonas Meisner, Anders Albrechtsen📨
Genome Res: 2023, 33(9);1599-1608
The reported variant has the largest population impact of any previously reported variant within a MODY gene. Together with the recessive TBC1D4 variant, we show that close to 1 in 5 cases of diabetes (18%) in Greenland are associated with high-impact genetic variants compared to 1-3% in large populations.
Anne Cathrine Baun Thuesen* , Frederik Filip Stæger* , …, Anders Albrechtsen📨, Ida Moltke📨, Torben Hansen📨
Lancet Reg Health Eur: 2023, 24;100529
news press release,
Due to its high frequency and large effect sizes, p.G137S has a marked population-level impact, increasing the risk of FH and cardiovascular disease for up to 30% of the Greenlandic population. Thus, p.G137S is a potential marker for early intervention in Arctic populations.
Emil Jørsboe, Mette K Andersen,…, Ida Moltke📨, Anders Albrechtsen📨, Torben Hansen📨
see press release and interview in HGG advances, polar journal diabetes.co.uk Sermitsiaq
Using sequencing data from simulations and closely related human populations, we show that our approach is better at distinguishing closely related populations than standard admixture and principal component analysis software. We further show that HaploNet is fast and highly scalable by applying it to genotype array data of the UK Biobank. U
Jonas Meisner📨, Anders Albrechtsen
Genome Res: 2022, 32(8);1542-52
We show that the genetic variant leads to lower weigth in both human and mice, that is lowers triglycerides considerably and that it leads to a much higher plasma acetate levels suggesting that the gut microbiome is causing the effect
Mette K Andersen* , Line Skotte* , Emil Jørsboe* ,…,Ida Moltke📨, Torben Hansen📨, Anders Albrechtsen📨
Gastroenterology: 2022, 162(4);1171-1182.e3
Nicely written Editorial by Johnny Le and Cholsoon Jang
news Daily mail, Polar journal , Natural Habitat, TV2 new in danish
Framework for joint determination of individual sex and sex-linked scaffolds for non-model organism based on depth of coverage
Nursyifa C.* ; Brüniche-Olsen A.* ; Garcia-Erill G.; Heller R.📨; Albrechtsen A.📨
journal highlight NEWS AND VIEWS
Which European ancestors have contributed to the genomes of modern day Greenlanders? The dutch?. The basque?, the Germans? Despite diverse contact almost all of the European genetic ancestry comes from Denmark.
Waples R.K.; Hauptmann A.L.; Seiding I.; Jørsboe E.; Jørgensen M.E.; Grarup N.; Andersen M.K.; Larsen C.V.L.; Bjerregaard P.; Hellenthal G.; Hansen T.📨; Albrechtsen A.📨; Moltke I.📨
PCA with rampant missingness including having samples with non overlapping data
Meisner J.; Liu S.; Huang M.; Albrechtsen A.
Evaluation your estimated admixture proportions. When running ADMIXTURE or NGSadmix you can evaluate the results.
Garcia-Erill G.; Albrechtsen A.
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression.
Grarup N.; Moltke I.; Andersen M.K.; Dalby M.; Vitting-Seerup K.; Kern T.; Mahendran Y.; Jørsboe E.; Larsen C.V.L.; Dahl-Petersen I.K.; Gilly A.; Suveges D.; Dedoussis G.; Zeggini E.; Pedersen O.; Andersson R.; Bjerregaard P.; Jørgensen M.E.; Albrechtsen A.📨; Hansen T.📨
Whole-genome sequencing data from 141,431 Chinese women generated for non-invasive prenatal testing (NIPT) for population genetic structure, GWAS maternal and infectious traits.
Liu S.; Huang S.; Chen F.; Zhao L.; Yuan Y.; Francis S.S.; Fang L.; Li Z.; Lin L.; Liu R.; Zhang Y.; Xu H.; Li S.; Zhou Y.; Davies R.W.; Liu Q.; Walters R.G.; Lin K.; Ju J.; Korneliussen T.; Yang M.A.; Fu Q.; Wang J.; Zhou L.; Krogh A.; Zhang H.; Wang W.; Chen Z.; Cai Z.; Yin Y.; Yang H.; Mao M.; Shendure J.; Wang J.📨; Albrechtsen A.📨; Jin X.📨; Nielsen R.📨; Xu X.📨
PCAngsd: PCA, admixture proportions, HWE or selection scans from low depth sequencings data while accomidating population structure
Meisner J.; Albrechtsen A.
The genetic consequences of population bottlenecks on patterns of deleterious genetic variation
Pedersen C.-E.T.; Lohmueller K.E.; Grarup N.; Bjerregaard P.; Hansen T.; Siegismund H.R.; Moltke I.; Albrechtsen A.
A weighted significance framework uses functional annotations to prioritize variants and increase the power of whole-genome association studies.
Sveinbjornsson G.; Albrechtsen A.; Zink F.; Gudjonsson S.A.; Oddson A.; Másson G.; Holm H.; Kong A.; Thorsteinsdottir U.; Sulem P.; Gudbjartsson D.F.; Stefansson K.
Genetic analyses of Greenlanders identify variants influencing red blood cell membrane fatty acids and connect fatty acid composition with metabolic traits.
Andersen M.K.; Jørsboe E.; Sandholt C.H.; Grarup N.; Jørgensen M.E.; Færgeman N.J.; Bjerregaard P.; Pedersen O.; Moltke I.; Hansen T.; Albrechtsen A.
Population-scale data reveal regional Inuit genetic structure, substantial recent European ancestry, and a single Inuit colonization route across Greenland.
Moltke I.; Fumagalli M.; Korneliussen T.S.; Crawford J.E.; Bjerregaard P.; Jørgensen M.E.; Grarup N.; Gulløv H.C.; Linneberg A.; Pedersen O.; Hansen T.📨; Nielsen R.📨; Albrechtsen A.📨
Genome sequencing shows that the Ancient One, also known as Kennewick Man, was more closely related to Native Americans than to any other population.
Rasmussen M.; Sikora M.; Albrechtsen A.; Korneliussen T.S.; Moreno-Mayar J.V.; Poznik G.D.; Zollikofer C.P.E.; Ponce De León M.S.; Allentoft M.E.; Moltke I.; Jónsson H.; Valdiosera C.; Malhi R.S.; Orlando L.; Bustamante C.D.; Stafford T.W., Jr.; Meltzer D.J.; Nielsen R.; Willerslev E.
Strong selection in fatty acid metabolism genes reflects Inuit adaptation to an Arctic environment and a traditional diet rich in marine fats.
Fumagalli M.; Moltke I.; Grarup N.; Racimo F.; Bjerregaard P.; Jørgensen M.E.; Korneliussen T.S.; Gerbault P.; Skotte L.; Linneberg A.; Christensen C.; Brandslund I.; Jørgensen T.; Huerta-Sánchez E.; Schmidt E.B.; Pedersen O.; Hansen T.📨; Albrechtsen A.📨; Nielsen R.📨
Ancient and modern genomes reconstruct the founding, diversification, and later gene flow that shaped Native American population history.
Raghavan M.; Steinrücken M.; Harris K.; Schiffels S.; Rasmussen S.; DeGiorgio M.; Albrechtsen A.; Valdiosera C.; Ávila-Arcos M.C.; Malaspinas A.-S.; … Manica A.; Durbin R.; Bustamante C.D.; Song Y.S.; Nielsen R.; Willerslev E.
Ancient genomes reveal a distinct Paleo-Eskimo migration into the Arctic, long-term genetic continuity, and later replacement by ancestors of present-day Inuit.
Raghavan M.; DeGiorgio M.; Albrechtsen A.; Moltke I.; Skoglund P.; Korneliussen T.S.; Grønnow B.; Appelt M.; Gulløv H.C.; Friesen T.M.; Fitzhugh W.; Malmström H.; Rasmussen S.; Olsen J.; Melchior L.; Fuller B.T.; Fahrni S.M.; Stafford T., Jr.; Grimes V.; Renouf M.A.P.; Cybulski J.; Lynnerup N.; Lahr M.M.; Britton K.; Knecht R.; Arneborg J.; Metspalu M.; Cornejo O.E.; Malaspinas A.-S.; Wang Y.; Rasmussen M.; Raghavan V.; Hansen T.V.O.; Khusnutdinova E.; Pierre T.; Dneprovsky K.; Andreasen C.; Lange H.; Hayes M.G.; Coltrain J.; Spitsyn V.A.; Götherström A.; Orlando L.; Kivisild T.; Villems R.; Crawford M.H.; Nielsen F.C.; Dissing J.; Heinemeier J.; Meldgaard M.; Bustamante C.; O’Rourke D.H.; Jakobsson M.; Gilbert M.T.P.; Nielsen R.; Willerslev E.
Image: ANGSD workflow from the NGS inference tutorial, MIT License.
Software for population genetic and medical genetic analysis of low depth sequencing data.
Korneliussen T.S.; Albrechtsen A.; Nielsen R.
Estimates pairwise relatedness between admixed individuals while accounting for population ancestry.
Moltke I.; Albrechtsen A.
A 24,000-year-old Siberian genome shows that Native American ancestors received ancestry from both East Asian and ancient western Eurasian-related populations.
Raghavan M.; Skoglund P.; Graf K.E.; Metspalu M.; Albrechtsen A.; Moltke I.; Rasmussen S.; Stafford T.W., Jr.; Orlando L.; Metspalu E.; Karmin M.; Tambets K.; Rootsi S.; Mägi R.; Campos P.F.; Balanovska E.; Balanovsky O.; Khusnutdinova E.; Litvinov S.; Osipova L.P.; Fedorova S.A.; Voevoda M.I.; Degiorgio M.; Sicheritz-Ponten T.; Brunak Sø.; Demeshchenko S.; Kivisild T.; Villems R.; Nielsen R.; Jakobsson M.; Willerslev E.
A common loss-of-function TBC1D4 variant in Greenlanders impairs muscle glucose uptake and greatly increases the risk of type 2 diabetes.
Moltke I.; Grarup N.; Jørgensen M.E.; Bjerregaard P.; Treebak J.T.; Fumagalli M.; Korneliussen T.S.; Andersen M.A.; Nielsen T.S.; Krarup N.T.; Gjesing A.P.; Zierath J.R.; Linneberg A.; Wu X.; Sun G.; Jin X.; Al-Aama J.; Wang J.; Borch-Johnsen K.; Pedersen O.; Nielsen R.📨; Albrechtsen A.📨; Hansen T.📨
Large-scale exome sequencing identifies coding variants in CD300LG, COBLL1, and MACF1 associated with lipid levels and type 2 diabetes.
Albrechtsen A.; Grarup N.; Li Y.; Sparsø T.; Tian G.; Cao H.; Jiang T.; Kim S.Y.; Korneliussen T.; Li Q.; Nie C.; Wu R.; Skotte L.; Morris A.P.; Ladenvall C.; Cauchi S.; Stančáková A.; Andersen G.; Astrup A.; Banasik K.; Bennett A.J.; Bolund L.; Charpentier G.; Chen Y.; Dekker J.M.; Doney A.S.F.; Dorkhan M.; Forsen T.; Frayling T.M.; Groves C.J.; Gui Y.; Hallmans G.; Hattersley A.T.; He K.; Hitman G.A.; Holmkvist J.; Huang S.; Jiang H.; Jin X.; Justesen J.M.; Kristiansen K.; Kuusisto J.; Lajer M.; Lantieri O.; Li W.; Liang H.; Liao Q.; Liu X.; Ma T.; Ma X.; Manijak M.P.; Marre M.; Mokrosiński J.; Morris A.D.; Mu B.; Nielsen A.A.; Nijpels G.; Nilsson P.; Palmer C.N.A.; Rayner N.W.; Renström F.; Ribel-Madsen R.; Robertson N.; Rolandsson O.; Rossing P.; Schwartz T.W.; Slagboom P.E.; Sterner M.; Tang M.; Tarnow L.; Tuomi T.; Van’T Riet E.; Van Leeuwen N.; Varga T.V.; Vestmar M.A.; Walker M.; Wang B.; Wang Y.; Wu H.; Xi F.; Yengo L.; Yu C.; Zhang X.; Zhang J.; Zhang Q.; Zhang W.; Zheng H.; Zhou Y.; Altshuler D.; ‘T Hart L.M.; Franks P.W.; Balkau B.; Froguel P.; McCarthy M.I.; Laakso M.; Groop L.; Christensen C.; Brandslund I.; Lauritzen T.; Witte D.R.; Linneberg A.; Jørgensen T.; Hansen T.; Wang J.; Nielsen R.; Pedersen O.
NGSadmix estimates individual ancestry proportions directly from genotype likelihoods in low-depth sequencing data.
Skotte L.; Korneliussen T.S.; Albrechtsen A.
Image: NGS inference tutorial workflow, MIT License.
A review of statistical methods for calling genotypes and SNPs while accounting for uncertainty in next-generation sequencing data.
Nielsen R.; Paul J.S.; Albrechtsen A.; Song Y.S.
A genome recovered from 4,000-year-old hair traces an early migration from Siberia into Greenland that was distinct from later Inuit expansion.
Rasmussen M.; Li Y.; Lindgreen S.; Pedersen J.S.; Albrechtsen A.; Moltke I.; Metspalu M.; Metspalu E.; Kivisild T.; Gupta R.; Bertalan M.; Nielsen K.; Gilbert M.T.P.; Wang Y.; Raghavan M.; Campos P.F.; Kamp H.M.; Wilson A.S.; Gledhill A.; Tridico S.; Bunce M.; Lorenzen E.D.; Binladen J.; Guo X.; Zhao J.; Zhang X.; Zhang H.; Li Z.; Chen M.; Orlando L.; Kristiansen K.; Bak M.; Tommerup N.; Bendixen C.; Pierre T.L.; Gronnow B.; Meldgaard M.; Andreasen C.; Fedorova S.A.; Osipova L.P.; Higham T.F.G.; Ramsey C.B.; Hansen T.V.O.; Nielsen F.C.; Crawford M.H.; Brunak S.; Sicheritz-Pont́n T.; Villems R.; Nielsen R.; Krogh A.; Wang J.; Willerslev E.
SNP discovery and genotype-calling biases can distort estimates of population differentiation and alter conclusions about demographic history.
Albrechtsen A.; Nielsen F.C.; Nielsen R.
Excess identity-by-descent sharing provides a way to detect recent natural selection, with the strongest signal found in the immune-related HLA region.
Albrechtsen A.; Moltke I.; Nielsen R.
Relate identifies local identity-by-descent tracts while accounting for linkage disequilibrium in genome-wide data.
Albrechtsen A.; Korneliussen T.S.; Moltke I.; van Overseem Hansen T.; Nielsen F.C.; Nielsen R.
A common variant near IRS1 links type 2 diabetes risk to reduced insulin signaling, insulin resistance, and elevated insulin levels.
Rung J.; Cauchi S.; Albrechtsen A.*; Shen L.; Rocheleau G.; Cavalcanti-Proença C.; Bacot F.; Balkau B.; Belisle A.; Borch-Johnsen K.; Charpentier G.; Dina C.; Durand E.; Elliott P.; Hadjadj S.; Järvelin M.-R.; Laitinen J.; Lauritzen T.; Marre M.; Mazur A.; Meyre D.; Montpetit A.; Pisinger C.; Posner B.; Poulsen P.; Pouta A.; Prentki M.; Ribel-Madsen R.; Ruokonen A.; Sandbaek A.; Serre D.; Tichet J.; Vaxillaire M.; Wojtaszewski J.F.P.; Vaag A.; Hansen T.; Polychronakos C.; Pedersen O.; Froguel P.; Sladek R.
The obesity-associated effect of the FTO risk variant is stronger in physically inactive people, highlighting an interaction between genes and lifestyle.
Andreasen C.H.; Stender-Petersen K.L.; Mogensen M.S.; Torekov S.S.; Wegner L.; Andersen G.; Nielsen A.L.; Albrechtsen A.; Borch-Johnsen K.; Rasmussen S.S.; Clausen J.O.; Sandbæk A.; Lauritzen T.; Hansen L.; Jørgensen T.; Pedersen O.; Hansen T.
Full List of publications
See google scholar for up to date publication list
1 Flexible read-aware genotype imputation from sequence using biobank sized reference panels
Li, Z.; Albrechtsen, A.; Davies, R.W.
Nature Communications 17, 524 (2026)
2 Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit
Stinson, S.E.; Balboa, R.F.; Andersen, M.K.; Stæger, F.F.; He, S.; Thuesen, A.C.B.; Lin, L.; Jørsboe, E.; Bjerregaard, P.; Larsen, C.V.L.; Grarup, N.; Jørgensen, M.E.; Moltke, I.; Albrechtsen, A.📨; Hansen, T.📨
The American Journal of Human Genetics 112(12), 2982-2994 (2025)
3 Pre-phasing long reads improves structural variant genotyping
Li, Z.📨, Stæger, F.F., Davies, R.W., Moltke, I.📨, & Albrechtsen, A📨.
Bioinformatics (2025)
4 Genomes of critically endangered saola are shaped by population structure and purging
Garcia-Erill, G., Liu, S., Le, M.D., Hurley, M.M., Nguyen, H.D., Nguyen, D.Q., Nguyen, D.H., Santander, C.G., Sánchez Barreiro, F., Gomes Martins, N.F., Hanghøj, K., Salleh, F.M., Ramos-Madrigal, J., Wang, X., Sinding, M.S., Morales, H.E., Stæger, F.F., Wilkinson, N., Meng, G., Pečnerová, P., Yang, C., Rasmussen, M.S., Schubert, M., Dunn, R.R., Moltke, I., Zhang, G., Chen, L., Wang, W., Cao, T.T., Nguyen, H.M., Siegismund, H.R., Albrechtsen, A.📨, Gilbert, M.T.📨, & Heller, R.📨
CELL (2025)
5 Polygenic risk score for type 2 diabetes shows context-dependent effects across populations
Boya Guo, Yanwei Cai, … , Frederik F Stæger … Ida Moltke … Anders Albrechtsen … Heather M Highland, Burcu F Darst
Nat Commun (2025)
6 High prevalence and common forms of maturity-onset diabetes of the young in Greenland
Thuesen, A.C.B.; Backe, M.B.; Garcia-Erill, G.; Schubert, M.; Hanghøj, K.E.; Moltke, I.; Albrechtsen, A.; Grarup, N.; Gjesing, A.P.; Jørgensen, M.E.; Hansen, T.; Pedersen, M.L.
Canadian Journal of Diabetes 49(3), 142-151.e2 (2025)
7 Genetic architecture in Greenland is shaped by demography, structure and selection
Stæger F.F.; Andersen M.K.; Li Z.; Hjerresen J.P.; He S.; Santander C.G.; Jensen R.T.; Rex K.F.; Thuesen A.C.B.; Hanghøj K.; Seiding I.H.; Jørsboe E.; Stinson S.E.; Rasmussen M.S.; Balboa R.F.; Larsen C.V.L.; Bjerregaard P.; Schubert M.; Meisner J.; Linneberg A.; Grarup N.; Zeggini E.; Nielsen R.; Jørgensen M.E.; Hansen T.📨; Moltke I.📨; Albrechtsen A.📨
Nature(2025)
8 Measuring linkage disequilibrium and improvement of pruning and clumping in structured populations
Ulises Bercovich, Malthe Sebro Rasmussen, Zilong Li, Carsten Wiuf, Anders Albrechtsen
Genetics, (2025) Pdf on my website
9 Sucrase Isomaltase Dysfunction Reduces Sucrose Intake in Mice and Humans
Aldiss P.; Torices L.; Ramne S.; Jørgensen M.E.; Bonfiglio F.; Burm H.; Esteban Blanco C.; Stæger F.F.V.; Senftleber N.K.; Treebak J.T.; Grarup N.; Bjerregaard P.; Grevengoed T.J.; Gillum M.P.; Moltke I.; Albrechtsen A.; Hansen T.; D’Amato M.; Andersen M.K.
Gastroenterology(2025)
10 Population genomics of the muskox’ resilience in the near absence of genetic variation
Pečnerová P.; Lord E.; Garcia-Erill G.; Hanghøj K.; Rasmussen M.S.; Meisner J.; Liu X.; van der Valk T.; Santander C.G.; Quinn L.; Lin L.; Liu S.; Carøe C.; Dalerum F.; Götherström A.; Måsviken J.; Vartanyan S.; Raundrup K.; Al-Chaer A.; Rasmussen L.; Hvilsom C.; Heide-Jørgensen M.P.; Sinding M.-H.S.; Aastrup P.; Van Coeverden de Groot P.J.; Schmidt N.M.; Albrechtsen A.; Dalén L.; Heller R.; Moltke I.; Siegismund H.R.
Mol. Eco.(2024)
11 Persistent Gene Flow Suggests an Absence of Reproductive Isolation in an African Antelope Speciation Model
Wang X.; Pedersen C.-E.T.; Athanasiadis G.; Garcia-Erill G.; Hanghøj K.; Bertola L.D.; Rasmussen M.S.; Schubert M.; Liu X.; Li Z.; Lin L.; Balboa R.F.; Jørsboe E.; Nursyifa C.; Liu S.; Muwanika V.; Masembe C.; Chen L.; Wang W.; Moltke I.; Siegismund H.R.; Albrechtsen A.📨; Heller R.📨
Systematic Biology(2024)
12 Extensive Population Structure Highlights an Apparent Paradox of Stasis in the Impala (Aepyceros melampus)
Garcia-Erill G.; Wang X.; Rasmussen M.; Quinn L.; Khan A.; Bertola L.; Santander C.; Balboa R.; Ogutu J.; Pečnerová P.; Hanghøj K.; Kuja J.; Nursyifa C.; Masembe C.; Muwanika V.; Bibi F.; Moltke I.; Siegismund H.; Albrechtsen A.📨; Heller R.📨
Mol. Eco.(2024)
13 Gut heavy metal and antibiotic resistome of humans living in the high Arctic
Hauptmann A.L.; Johansen J.; Stæger F.F.; Nielsen D.S.; Mulvad G.; Hanghøj K.; Rasmussen S.; Hansen T.; Albrechtsen A.
Frontiers in Microbiology(2024)
14 NK2R control of energy expenditure and feeding to treat metabolic diseases
Sass F.; Ma T.; Ekberg J.H.; Kirigiti M.; Ureña M.G.; Dollet L.; Brown J.M.; Basse A.L.; Yacawych W.T.; Burm H.B.; Andersen M.K.; Nielsen T.S.; Tomlinson A.J.; Dmytiyeva O.; Christensen D.P.; Bader L.; Vo C.T.; Wang Y.; Rausch D.M.; Kristensen C.K.; Gestal-Mato M.; In het Panhuis W.; Sjøberg K.A.; Kernodle S.; Petersen J.E.; Pavlovskyi A.; Sandhu M.; Moltke I.; Jørgensen M.E.; Albrechtsen A.; Grarup N.; Babu M.M.; Rensen P.C.N.; Kooijman S.; Seeley R.J.; Worthmann A.; Heeren J.; Pers T.H.; Hansen T.; Gustafsson M.B.F.; Tang-Christensen M.; Kilpeläinen T.O.; Myers M.G., Jr.; Kievit P.; Schwartz T.W.; Hansen J.B.; Gerhart-Hines Z.
Nature(2024)
15 Utilizing non-invasive prenatal test sequencing data for human genetic investigation
Liu, S.; Liu, Y.; Gu, Y.; Lin, X.; Zhu, H.; Liu, H.; Xu, Z.; Cheng, S.; Lan, X.; Li, L.; Huang, M.; Li, H.; Nielsen, R.; Davies, R.W.; Albrechtsen, A.; Chen, G.-B.; Qiu, X.; Jin, X.; Huang, S.
Cell Genomics 4(10), 100669 (2024)
16 Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans
Long Lin, Mette K. Andersen, Frederik Filip Stæger, Zilong Li, Kristian Hanghøj, Allan Linneberg, Niels Grarup, Marit Eika Jørgensen, Torben Hansen📨, Ida Moltke📨 & Anders Albrechtsen📨
Genome Med 16, 71 (2024).
17 Introgression and disruption of migration routes have shaped the genetic integrity of wildebeest populations.
Xiaodong Liu* , Long Lin* , Mikkel-Holger S. Sinding* , Laura D. Bertola, Kristian Hanghøj, Liam Quinn, Genís Garcia-Erill, Malthe Sebro Rasmussen, Mikkel Schubert, Patrícia Pečnerová, Renzo F. Balboa, Zilong Li, Michael P. Heaton, Timothy P. L. Smith, Rui Resende Pinto, Xi Wang, Josiah Kuja, Anna Brüniche-Olsen, Jonas Meisner, Cindy G. Santander, Joseph O. Ogutu, Charles Masembe, Rute R. da Fonseca, Vincent Muwanika, Hans R. Siegismund, Anders Albrechtsen📨, Ida Moltke📨, Rasmus Heller📨
Nature Communications 15, 2921 (2024)
18 Giraffe lineages are shaped by major ancient admixture events
Laura D. Bertola* , Liam Quinn* , Kristian Hanghøj* , Genís Garcia-Erill, Malthe Sebro Rasmussen, Renzo F. Balboa, Jonas Meisner, Thomas Bøggild, Xi Wang, Long Lin, Casia Nursyifa, Xiaodong Liu, Zilong Li, Mumbi Chege, Yoshan Moodley, Anna Brüniche-Olsen, Josiah Kuja, Mikkel Schubert, Morris Agaba, Cindy G. Santander, Mikkel-Holger S. Sinding, Vincent Muwanika, Charles Masembe, Hans R. Siegismund, Ida Moltke 📨 , Anders Albrechtsen 📨, Rasmus Heller 📨,
Current Biology,2024
19 African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival
Balboa* , Bertola* , Brüniche-Olsen* , … Moltke 📨, Albrechtsen 📨, Heller 📨;
Nature Communications 15, 172 (2024)
20 Estimating admixture pedigrees of recent hybrids without a contiguous reference genome
Genís Garcia-Erill📨, Kristian Hanghøj, Rasmus Heller, Carsten Wiuf, Anders Albrechtsen
Mol Ecol Resour 23(7) 2023
21 Evaluation of population structure inferred by principal component analysis or the admixture model.
Jan van Waaij* 📨, Song Li* , Genís Garcia-Erill* , Anders Albrechtsen, Carsten Wiuf📨;
Genetics: 2023, 225(2);
22 Fast and accurate out-of-core PCA framework for large scale biobank data.
Zilong Li📨, Jonas Meisner, Anders Albrechtsen📨
Genome Res: 2023, 33(9);1599-1608
23 A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
Anne Cathrine Baun Thuesen* , Frederik Filip Stæger* , …, Anders Albrechtsen📨, Ida Moltke📨, Torben Hansen📨
Lancet Reg Health Eur: 2023, 24;100529
24 An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention
Emil Jørsboe, Mette K Andersen,…, Ida Moltke📨, Anders Albrechtsen📨, Torben Hansen📨
HGG Adv: 2022, 3(4);100118
25 Haplotype and population structure inference using neural networks in whole-genome sequencing data.
Jonas Meisner📨, Anders Albrechtsen
Genome Res: 2022, 32(8);1542-52
26 Loss of Sucrase-Isomaltase Function Increases Acetate Levels and Improves Metabolic Health in Greenlandic Cohorts.
Mette K Andersen* , Line Skotte* , Emil Jørsboe* ,…,Ida Moltke📨, Torben Hansen📨, Anders Albrechtsen📨
Gastroenterology: 2022, 162(4);1171-1182.e3
27 Population genomics of the muskox’ resilience in the near absence of genetic variation
Pečnerová P.; Lord E.; Garcia-Erill G.; Hanghøj K.; Rasmussen M.S.; Meisner J.; Liu X.; van der Valk T.; Santander C.G.; Quinn L.; Lin L.; Liu S.; Carøe C.; Dalerum F.; Götherström A.; Måsviken J.; Vartanyan S.; Raundrup K.; Al-Chaer A.; Rasmussen L.; Hvilsom C.; Heide-Jørgensen M.P.; Sinding M.-H.S.; Aastrup P.; Van Coeverden de Groot P.J.; Schmidt N.M.; Albrechtsen A.; Dalén L.; Heller R.; Moltke I.; Siegismund H.R.
Mol. Eco.(2023)
28 Genetic Loss of Sucrase-Isomaltase Function: Mechanisms, Implications, and Future Perspectives
Senftleber N.K.; Ramne S.; Moltke I.; Jørgensen M.E.; Albrechtsen A.; Hansen T.; Andersen M.K.
Appl Clin Genet(2023)
29 Identifying the genetic causes of phenotypically diagnosed Pakistani mucopolysaccharidoses patients by whole genome sequencing
Gul R.; Firasat S.; Schubert M.; Ullah A.; Peña E.; Thuesen A.C.B.; Hussain M.; Staeger F.F.; Gjesing A.P.; Albrechtsen A.; Hansen T.
Front. genet(2023)
30 GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal
Senftleber N.K.; Andersen M.K.; Jørsboe E.; Stæger F.F.; Nøhr A.K.; Garcia-Erill G.; Meisner J.; Santander C.G.; Balboa R.F.; Gilly A.; Bjerregaard P.; Larsen C.V.L.; Grarup N.; Jørgensen M.E.; Zeggini E.; Moltke I.📨; Hansen T.📨; Albrechtsen A.📨
EJHG(2023)
31 Colonialism in South Africa leaves a lasting legacy of reduced genetic diversity in Cape buffalo
Quinn L.; Garcia-Erill G.; Santander C.; Brüniche-Olsen A.; Liu X.; Sinding M.-H.S.; Heaton M.P.; Smith T.P.L.; Pečnerová P.; Bertola L.D.; Hanghøj K.; Rasmussen M.S.; de Jager D.; Siegismund H.R.; Albrechtsen A.📨; Heller R.📨; Moltke I.📨
Mol. Eco.(2023)
32 Polygenic heterogeneity in antidepressant treatment and placebo response
Nøhr A.K.; Forsingdal A.; Moltke I.; Howes O.D.; Vitezic M.; Albrechtsen A.; Dalby M.
Transl. Psychiatry(2022)
33 Warthog Genomes Resolve an Evolutionary Conundrum and Reveal Introgression of Disease Resistance Genes
Garcia-Erill G.; Jørgensen C.H.F.; Muwanika V.B.; Wang X.; Rasmussen M.S.; De Jong Y.A.; Gaubert P.; Olayemi A.; Salmona J.; Butynski T.M.; Bertola L.D.; Siegismund H.R.; Albrechtsen A.; Heller R.
Mol Biol Evol(2022)
34 Joint identification of sex and sex-linked scaffolds in non-model organisms using low depth sequencing data
Nursyifa C.* ; Brüniche-Olsen A.* ; Garcia-Erill G.; Heller R.📨; Albrechtsen A.📨
Mol. Eco. res(2022)
35 Estimation of site frequency spectra from low-coverage sequencing data using stochastic EM reduces overfitting, runtime, and memory usage
Rasmussen M.S.; Garcia-Erill G.; Korneliussen T.S.; Wiuf C.; Albrechtsen A.
Genetics(2022)
36 Efficient approaches for large-scale GWAS with genotype uncertainty
Jørsboe E.; Albrechtsen A.
G3(2022)
37 Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic
Duncan C.J.A.; Skouboe M.K.; Howarth S.; Hollensen A.K.; Chen R.; Børresen M.L.; Thompson B.J.; Stremenova Spegarova J.; Hatton C.F.; Stæger F.F.; Andersen M.K.; Whittaker J.; Paludan S.R.; Jørgensen S.E.; Thomsen M.K.; Mikkelsen J.G.; Heilmann C.; Buhas D.; Øbro N.F.; Bay J.T.; Marquart H.V.; Teresa de la Morena M.; Klejka J.A.; Hirschfeld M.; Borgwardt L.; Forss I.; Masmas T.; Poulsen A.; Noya F.; Rouleau G.; Hansen T.; Zhou S.; Albrechtsen A.; Alizadehfar R.; Allenspach E.J.; Hambleton S.; Mogensen T.H.
JEM(2022)
38 A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder
Nøhr A.K.; Lindow M.; Forsingdal A.; Demharter S.; Nielsen T.; Buller R.; Moltke I.; Vitezic M.; Albrechtsen A.
Neuropsychopharmacology(2021)
39 Predictors and trajectories of treatment response to SSRIs in patients suffering from PTSD
Nøhr A.K.; Eriksson H.; Hobart M.; Moltke I.; Buller R.; Albrechtsen A.; Lindgreen S.
Psychiatry Res(2021)
40 The genetic history of Greenlandic-European contact
Waples R.K.; Hauptmann A.L.; Seiding I.; Jørsboe E.; Jørgensen M.E.; Grarup N.; Andersen M.K.; Larsen C.V.L.; Bjerregaard P.; Hellenthal G.; Hansen T.📨; Albrechtsen A.📨; Moltke I.📨
Current Biology(2021)
41 Vicariance followed by secondary gene flow in a young gazelle species complex
Garcia-Erill G.; Kjær M.M.; Albrechtsen A.; Siegismund H.R.; Heller R.
Mol. Eco.(2021)
42 Detecting selection in low-coverage high-throughput sequencing data using principal component analysis
Meisner J.; Albrechtsen A.; Hanghøj K.
BMC Bioinformatics(2021)
43 High genetic diversity and low differentiation reflect the ecological versatility of the African leopard
Pečnerová P.; Garcia-Erill G.; Liu X.; Nursyifa C.; Waples R.K.; Santander C.G.; Quinn L.; Frandsen P.; Meisner J.; Stæger F.F.; Rasmussen M.S.; Brüniche-Olsen A.; Hviid Friis Jørgensen C.; da Fonseca R.R.; Siegismund H.R.; Albrechtsen A.; Heller R.; Moltke I.; Hanghøj K.
Current Biology(2021)
44 Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers
Schnurr T.M.; Jørsboe E.; Chadt A.; Dahl-Petersen I.K.; Kristensen J.M.; Wojtaszewski J.F.P.; Springer C.; Bjerregaard P.; Brage S.; Pedersen O.; Moltke I.; Grarup N.; Al-Hasani H.; Albrechtsen A.; Jørgensen M.E.; Hansen T.
Diabetologia(2021)
45 A reference-free approach to analyse RADseq data using standard next generation sequencing toolkits
Heller R.; Nursyifa C.; Garcia-Erill G.; Salmona J.; Chikhi L.; Meisner J.; Korneliussen T.S.; Albrechtsen A.
Mol. Eco. res(2021)
46 Large-scale inference of population structure in presence of missingness using PCA
Meisner J.; Liu S.; Huang M.; Albrechtsen A.
Bioinformatics(2021)
47 NGSremix: A software tool for estimating pairwise relatedness between admixed individuals from next-generation sequencing data
Nøhr A.K.; Hanghøj K.; Garcia-Erill G.; Li Z.; Moltke I.; Albrechtsen A.
G3(2021)
48 Evaluation of model fit of inferred admixture proportions
Garcia-Erill G.; Albrechtsen A.
Mol. Eco. res(2020)
49 Population genomics of the Viking world
Margaryan A.; Lawson D.J.; Sikora M.; Racimo F.; Rasmussen S.; Moltke I.; Cassidy L.M.; Jørsboe E.; Ingason A.; Pedersen M.W.; Korneliussen T.; Wilhelmson H.; Buś M.M.; de Barros Damgaard P.; Martiniano R.; Renaud G.; Bhérer C.; Moreno-Mayar J.V.; Fotakis A.K.; Allen M.; Allmäe R.; Molak M.; Cappellini E.; Scorrano G.; McColl H.; Buzhilova A.; Fox A.; Albrechtsen A.; Schütz B.; Skar B.; Arcini C.; Falys C.; Jonson C.H.; Błaszczyk D.; Pezhemsky D.; Turner-Walker G.; Gestsdóttir H.; Lundstrøm I.; Gustin I.; Mainland I.; Potekhina I.; Muntoni I.M.; Cheng J.; Stenderup J.; Ma J.; Gibson J.; Peets J.; Gustafsson J.; Iversen K.H.; Simpson L.; Strand L.; Loe L.; Sikora M.; Florek M.; Vretemark M.; Redknap M.; Bajka M.; Pushkina T.; Søvsø M.; Grigoreva N.; Christensen T.; Kastholm O.; Uldum O.; Favia P.; Holck P.; Sten S.; Arge S.V.; Ellingvåg S.; Moiseyev V.; Bogdanowicz W.; Magnusson Y.; Orlando L.; Pentz P.; Jessen M.D.; Pedersen A.; Collard M.; Bradley D.G.; Jørkov M.L.; Arneborg J.; Lynnerup N.; Price N.; Gilbert M.T.P.; Allentoft M.E.; Bill J.; Sindbæk S.M.; Hedeager L.; Kristiansen K.; Nielsen R.; Werge T.; Willerslev E.
Nature(2020)
50 Omega-3 fatty acids and risk of cardiovascular disease in Inuit: First prospective cohort study
Senftleber N.K.; Albrechtsen A.; Lauritzen L.; Larsen C.L.; Bjerregaard P.; Diaz L.J.; Rønn P.F.; Jørgensen M.E.
Atherosclerosis(2020)
51 The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders
Andersen M.K.; Jørsboe E.; Skotte L.; Hanghøj K.; Sandholt C.H.; Moltke I.; Grarup N.; Kern T.; Mahendran Y.; Søborg B.; Bjerregaard P.; Larsen C.V.L.; Dahl-Petersen I.K.; Tiwari H.K.; Feenstra B.; Koch A.; Wiener H.W.; Hopkins S.E.; Pedersen O.; Melbye M.; Boyer B.B.; Jørgensen M.E.; Albrechtsen A.📨; Hansen T.📨
PLoS Genetics(2020)
52 Estimating narrow-sense heritability using family data from admixed populations
Athanasiadis G.; Speed D.; Andersen M.K.; Appel E.V.R.; Grarup N.; Brandslund I.; Jørgensen M.E.; Larsen C.V.L.; Bjerregaard P.; Hansen T.; Albrechtsen A.
Heredity(2020)
53 Genetic study of the Arctic CPT1A variant suggests that its effect on fatty acid levels is modulated by traditional Inuit diet
Senftleber N.; Jørgensen M.E.; Jørsboe E.; Imamura F.; Forouhi N.G.; Larsen C.L.; Bjerregaard P.; Hansen T.📨; Albrechtsen A.📨
EJHG(2020)
54 A likelihood method for estimating present-day human contamination in ancient male samples using low-depth X-chromosome data
Moreno-Mayar J.V.; Korneliussen T.S.; Dalal J.; Renaud G.; Albrechtsen A.; Nielsen R.; Malaspinas A.-S.
Bioinformatics(2020)
55 DamMet: Ancient methylome mapping accounting for errors, true variants, and post-mortem DNA damage
Hanghøj K.; Renaud G.; Albrechtsen A.; Orlando L.
GigaScience(2019)
56 Ancestry-specific association mapping in admixed populations
Skotte L.; Jørsboe E.; Korneliussen T.S.; Moltke I.; Albrechtsen A.
Genetic Epidemiology(2019)
57 Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing
Enroth C.; Poulsen L.D.; Iversen S.; Kirpekar F.; Albrechtsen A.; Vinther J.
NAR(2019)
58 Allele frequency-free inference of close familial relationships from genotypes or low-depth sequencing data
Waples R.K.; Albrechtsen A.; Moltke I.
Mol. Eco.(2019)
59 Genomic diversity and novel genome-wide association with fruit morphology in Capsicum, from 746k polymorphic sites
Colonna V.; D’Agostino N.; Garrison E.; Albrechtsen A.; Meisner J.; Facchiano A.; Cardi T.; Tripodi P.
Sci Rep.(2019)
60 Testing for Hardy–Weinberg equilibrium in structured populations using genotype or low-depth next generation sequencing data
Meisner J.; Albrechtsen A.
Mol. Eco. res(2019)
61 Powerful inference with the D-statistic on low-coverage whole-genome data
Soraggi S.; Wiuf C.; Albrechtsen A.
G3(2018)
62 Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans
Moreno-Mayar J.V.; Potter B.A.; Vinner L.; Steinrücken M.; Rasmussen S.; Terhorst J.; Kamm J.A.; Albrechtsen A.; Malaspinas A.-S.; Sikora M.; Reuther J.D.; Irish J.D.; Malhi R.S.; Orlando L.; Song Y.S.; Nielsen R.; Meltzer D.J.; Willerslev E.
Nature(2018)
63 Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population
Grarup N.; Moltke I.; Andersen M.K.; Bjerregaard P.; Larsen C.V.L.; Dahl-Petersen I.K.; Jørsboe E.; Tiwari H.K.; Hopkins S.E.; Wiener H.W.; Boyer B.B.; Linneberg A.; Pedersen O.; Jørgensen M.E.; Albrechtsen A.; Hansen T.
Diabetologia(2018)
64 Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
Grarup N.; Moltke I.; Andersen M.K.; Dalby M.; Vitting-Seerup K.; Kern T.; Mahendran Y.; Jørsboe E.; Larsen C.V.L.; Dahl-Petersen I.K.; Gilly A.; Suveges D.; Dedoussis G.; Zeggini E.; Pedersen O.; Andersson R.; Bjerregaard P.; Jørgensen M.E.; Albrechtsen A.📨; Hansen T.📨
Nature Genetics(2018)
65 Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History
Liu S.; Huang S.; Chen F.; Zhao L.; Yuan Y.; Francis S.S.; Fang L.; Li Z.; Lin L.; Liu R.; Zhang Y.; Xu H.; Li S.; Zhou Y.; Davies R.W.; Liu Q.; Walters R.G.; Lin K.; Ju J.; Korneliussen T.; Yang M.A.; Fu Q.; Wang J.; Zhou L.; Krogh A.; Zhang H.; Wang W.; Chen Z.; Cai Z.; Yin Y.; Yang H.; Mao M.; Shendure J.; Wang J.📨; Albrechtsen A.📨; Jin X.📨; Nielsen R.📨; Xu X.📨
Cell(2018)
66 Inferring population structure and admixture proportions in low-depth NGS data
Meisner J.; Albrechtsen A.
Genetics(2018)
67 Ancient genomes revisit the ancestry of domestic and Przewalski’s horses
Gaunitz C.; Fages A.; Hanghøj K.; Albrechtsen A.; Khan N.; Schubert M.; Seguin-Orlando A.; Owens I.J.; Felkel S.; Bignon-Lau O.; Damgaard P.D.B.; Mittnik A.; Mohaseb A.F.; Davoudi H.; Alquraishi S.; Alfarhan A.H.; Al-Rasheid K.A.S.; Crubézy E.; Benecke N.; Olsen S.; Brown D.; Anthony D.; Massy K.; Pitulko V.; Kasparov A.; Brem G.; Hofreiter M.; Mukhtarova G.; Baimukhanov N.; Lõugas L.; Onar V.; Stockhammer P.W.; Krause J.; Boldgiv B.; Undrakhbold S.; Erdenebaatar D.; Lepetz S.; Mashkour M.; Ludwig A.; Wallner B.; Merz V.; Merz I.; Zaibert V.; Willerslev E.; Librado P.; Outram A.K.; Orlando L.
Science(2018)
68 A southern African origin and cryptic structure in the highly mobile plains zebra
Pedersen C.-E.T.; Albrechtsen A.; Etter P.D.; Johnson E.A.; Orlando L.; Chikhi L.; Siegismund H.R.; Heller R.
Nature E&E(2018)
69 Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population
Appel E.V.R.; Moltke I.; Jørgensen M.E.; Bjerregaard P.; Linneberg A.; Pedersen O.; Albrechtsen A.; Hansen T.; Grarup N.
EJHG(2018)
70 Genetic architecture of obesity and related metabolic traits — recent insights from isolated populations
Andersen M.K.; Grarup N.; Moltke I.; Albrechtsen A.; Hansen T.
Curr Opin Genetics Dev(2018)
71 Archaic adaptive introgression in TBX15/WARS2
Racimo F.; Gokhman D.; Fumagalli M.; Ko A.; Hansen T.; Moltke I.; Albrechtsen A.; Carmel L.; Huerta-Sanchez E.; Nielsen R.
Mol Biol Evol(2017)
72 Founder Effect of the RETC611Y Mutation in Multiple Endocrine Neoplasia 2A in Denmark: A Nationwide Study
Mathiesen J.S.; Kroustrup J.P.; Vestergaard P.; Stochholm K.; Poulsen P.L.; Rasmussen A.K.; Feldt-Rasmussen U.; Gaustadnes M.; Ørntoft T.F.; Rossing M.; Nielsen F.C.; Albrechtsen A.; Brixen K.; Godballe C.; Frederiksen A.L.
Thyroid(2017)
73 FastNGSadmix: Admixture proportions and principal component analysis of a single NGS sample
Jørsboe E.; Hanghøj K.; Albrechtsen A.
Bioinformatics(2017)
74 Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers
Sikora M.; Seguin-Orlando A.; Sousa V.C.; Albrechtsen A.; Korneliussen T.; Ko A.; Rasmussen S.; Dupanloup I.; Nigst P.R.; Bosch M.D.; Renaud G.; Allentoft M.E.; Margaryan A.; Vasilyev S.V.; Veselovskaya E.V.; Borutskaya S.B.; Deviese T.; Comeskey D.; Higham T.; Manica A.; Foley R.; Meltzer D.J.; Nielsen R.; Excoffier L.; Lahr M.M.; Orlando L.; Willerslev E.
Science(2017)
75 Genetic screening of the FLCN gene identify six novel variants and a Danish founder mutation
Rossing M.; Albrechtsen A.; Skytte A.-B.; Jensen U.B.; Ousager L.B.; Gerdes A.-M.; Nielsen F.C.; Hansen T.V.
J Hum genet(2017)
76 Ancient genomic changes associated with domestication of the horse
Librado P.; Gamba C.; Gaunitz C.; Der Sarkissian C.; Pruvost M.; Albrechtsen A.; Fages A.; Khan N.; Schubert M.; Jagannathan V.; Serres-Armero A.; Kuderna L.F.K.; Povolotskaya I.S.; Seguin-Orlando A.; Lepetz S.; Neuditschko M.; Thèves C.; Alquraishi S.; Alfarhan A.H.; Al-Rasheid K.; Rieder S.; Samashev Z.; Francfort H.-P.; Benecke N.; Hofreiter M.; Ludwig A.; Keyser C.; Marques-Bonet T.; Ludes B.; Crubézy E.; Leeb T.; Willerslev E.; Orlando L.
Science(2017)
77 The effect of an extreme and prolonged population bottleneck on patterns of deleterious variation: Insights from the Greenlandic Inuit
Pedersen C.-E.T.; Lohmueller K.E.; Grarup N.; Bjerregaard P.; Hansen T.; Siegismund H.R.; Moltke I.; Albrechtsen A.
Genetics(2017)
78 Weighting sequence variants based on their annotation increases power of whole-genome association studies
Sveinbjornsson G.; Albrechtsen A.; Zink F.; Gudjonsson S.A.; Oddson A.; Másson G.; Holm H.; Kong A.; Thorsteinsdottir U.; Sulem P.; Gudbjartsson D.F.; Stefansson K.
Nature Genetics(2016)
79 Estimating IBD tracts from low coverage NGS data
Vieira F.G.; Albrechtsen A.; Nielsen R.
Bioinformatics(2016)
80 Genetics of Type 2 Diabetes: the Power of Isolated Populations
Andersen M.K.; Pedersen C.-E.T.; Moltke I.; Hansen T.; Albrechtsen A.; Grarup N.
Current Diabetes Reports(2016)
81 Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders
Andersen M.K.; Jørsboe E.; Sandholt C.H.; Grarup N.; Jørgensen M.E.; Færgeman N.J.; Bjerregaard P.; Pedersen O.; Moltke I.; Hansen T.; Albrechtsen A.
PLoS Genetics(2016)
82 Next-generation biology: Sequencing and data analysis approaches for non-model organisms
da Fonseca R.R.; Albrechtsen A.; Themudo G.E.; Ramos-Madrigal J.; Sibbesen J.A.; Maretty L.; Zepeda-Mendoza M.L.; Campos P.F.; Heller R.; Pereira R.J.
Mar Genomics(2016)
83 A genomic history of Aboriginal Australia
Malaspinas A.-S.; Westaway M.C.; Muller C.; Sousa V.C.; Lao O.; Alves I.; Bergström A.; Athanasiadis G.; Cheng J.Y.; Crawford J.E.; Heupink T.H.; MacHoldt E.; Peischl S.; Rasmussen S.; Schiffels S.; Subramanian S.; Wright J.L.; Albrechtsen A.; Barbieri C.; Dupanloup I.; Eriksson A.; Margaryan A.; Moltke I.; Pugach I.; Korneliussen T.S.; Levkivskyi I.P.; Moreno-Mayar J.V.; Ni S.; Racimo F.; Sikora M.; Xue Y.; Aghakhanian F.A.; Brucato N.; Brunak Sø.; Campos P.F.; Clark W.; Ellingvåg S.; Fourmile G.; Gerbault P.; Injie D.; Koki G.; Leavesley M.; Logan B.; Lynch A.; Matisoo-Smith E.A.; McAllister P.J.; Mentzer A.J.; Metspalu M.; Migliano A.B.; Murgha L.; Phipps M.E.; Pomat W.; Reynolds D.; Ricaut F.-X.; Siba P.; Thomas M.G.; Wales T.; Wall C.M.; Oppenheimer S.J.; Tyler-Smith C.; Durbin R.; Dortch J.; Manica A.; Schierup M.H.; Foley R.A.; Lahr M.M.; Bowern C.; Wall J.D.; Mailund T.; Stoneking M.; Nielsen R.; Sandhu M.S.; Excoffier L.; Lambert D.M.; Willerslev E.
Nature(2016)
84 Diabetes in population isolates: Lessons from Greenland
Grarup N.; Moltke I.; Albrechtsen A.; Hansen T.
Review of Diabetic Studies(2015)
85 Evolutionary genomics and conservation of the endangered Przewalski’s horse
Der Sarkissian C.; Ermini L.; Schubert M.; Yang M.A.; Librado P.; Fumagalli M.; Jónsson H.; Bar-Gal G.K.; Albrechtsen A.; Vieira F.G.; Petersen B.; Ginolhac A.; Seguin-Orlando A.; Magnussen K.; Fages A.; Gamba C.; Lorente-Galdos B.; Polani S.; Steiner C.; Neuditschko M.; Jagannathan V.; Feh C.; Greenblatt C.L.; Ludwig A.; Abramson N.I.; Zimmermann W.; Schafberg R.; Tikhonov A.; Sicheritz-Ponten T.; Willerslev E.; Marques-Bonet T.; Ryder O.A.; McCue M.; Rieder S.; Leeb T.; Slatkin M.; Orlando L.
Current Biology(2015)
86 Partial USH2A deletions contribute to Usher syndrome in Denmark
Dad S.; Rendtorff N.D.; Kann E.; Albrechtsen A.; Mehrjouy M.M.; Bak M.; Tommerup N.; Tranebjærg L.; Rosenberg T.; Jensen H.; Møller L.B.
EJHG(2015)
87 Uncovering the genetic history of the present-day greenlandic population
Moltke I.; Fumagalli M.; Korneliussen T.S.; Crawford J.E.; Bjerregaard P.; Jørgensen M.E.; Grarup N.; Gulløv H.C.; Linneberg A.; Pedersen O.; Hansen T.📨; Nielsen R.📨; Albrechtsen A.📨
AJHG(2015)
88 Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments
Librado P.; Der Sarkissian C.; Ermini L.; Schubert M.; Jónsson H.; Albrechtsen A.; Fumagalli M.; Yang M.A.; Gamba C.; Seguin-Orlando A.; Mortensen C.D.; Petersen B.; Hoove C.A.; Lorente-Galdos B.; Nedoluzhko A.; Boulygina E.; Tsygankova S.; Neuditschko M.; Jagannathan V.; Thèves C.; Alfarhan A.H.; Alquraishi S.A.; Al-Rasheid K.A.S.; Sicheritz-Ponten T.; Popov R.; Grigoriev S.; Alekseev A.N.; Rubin E.M.; McCue M.; Rieder S.; Leeb T.; Tikhonov A.; Crubézy E.; Slatkin M.; Marques-Bonet T.; Nielsen R.; Willerslev E.; Kantanen J.; Prokhortchouk E.; Orlando L.
PNAS(2015)
89 The ancestry and affiliations of Kennewick Man
Rasmussen M.; Sikora M.; Albrechtsen A.; Korneliussen T.S.; Moreno-Mayar J.V.; Poznik G.D.; Zollikofer C.P.E.; Ponce De León M.S.; Allentoft M.E.; Moltke I.; Jónsson H.; Valdiosera C.; Malhi R.S.; Orlando L.; Bustamante C.D.; Stafford T.W., Jr.; Meltzer D.J.; Nielsen R.; Willerslev E.
Nature(2015)
90 The origin and evolution of maize in the Southwestern United States
Da Fonseca R.R.; Smith B.D.; Wales N.; Cappellini E.; Skoglund P.; Fumagalli M.; Samaniego J.A.; Carøe C.; Ávila-Arcos M.C.; Hufnagel D.E.; Korneliussen T.S.; Vieira F.G.; Jakobsson M.; Arriaza B.; Willerslev E.; Nielsen R.; Hufford M.B.; Albrechtsen A.; Ross-Ibarra J.; Gilbert M.T.P.
Nature Plants(2015)
91 Greenlandic Inuit show genetic signatures of diet and climate adaptation
Fumagalli M.; Moltke I.; Grarup N.; Racimo F.; Bjerregaard P.; Jørgensen M.E.; Korneliussen T.S.; Gerbault P.; Skotte L.; Linneberg A.; Christensen C.; Brandslund I.; Jørgensen T.; Huerta-Sánchez E.; Schmidt E.B.; Pedersen O.; Hansen T.📨; Albrechtsen A.📨; Nielsen R.📨
Science(2015)
92 Genomic evidence for the Pleistocene and recent population history of Native Americans
Raghavan M.; Steinrücken M.; Harris K.; Schiffels S.; Rasmussen S.; DeGiorgio M.; Albrechtsen A.; Valdiosera C.; Ávila-Arcos M.C.; Malaspinas A.-S.; … Manica A.; Durbin R.; Bustamante C.D.; Song Y.S.; Nielsen R.; Willerslev E.
Science(2015)
93 Genomic structure in Europeans dating back at least 36,200 years
Seguin-Orlando A.; Korneliussen T.S.; Sikora M.; Malaspinas A.-S.; Manica A.; Moltke I.; Albrechtsen A.; Ko A.; Margaryan A.; Moiseyev V.; Goebel T.; Westaway M.; Lambert D.; Khartanovich V.; Wall J.D.; Nigst P.R.; Foley R.A.; Lahr M.M.; Nielsen R.; Orlando L.; Willerslev E.
Science(2014)
94 The genetic prehistory of the New World Arctic
Raghavan M.; DeGiorgio M.; Albrechtsen A.; Moltke I.; Skoglund P.; Korneliussen T.S.; Grønnow B.; Appelt M.; Gulløv H.C.; Friesen T.M.; Fitzhugh W.; Malmström H.; Rasmussen S.; Olsen J.; Melchior L.; Fuller B.T.; Fahrni S.M.; Stafford T., Jr.; Grimes V.; Renouf M.A.P.; Cybulski J.; Lynnerup N.; Lahr M.M.; Britton K.; Knecht R.; Arneborg J.; Metspalu M.; Cornejo O.E.; Malaspinas A.-S.; Wang Y.; Rasmussen M.; Raghavan V.; Hansen T.V.O.; Khusnutdinova E.; Pierre T.; Dneprovsky K.; Andreasen C.; Lange H.; Hayes M.G.; Coltrain J.; Spitsyn V.A.; Götherström A.; Orlando L.; Kivisild T.; Villems R.; Crawford M.H.; Nielsen F.C.; Dissing J.; Heinemeier J.; Meldgaard M.; Bustamante C.; O’Rourke D.H.; Jakobsson M.; Gilbert M.T.P.; Nielsen R.; Willerslev E.
Science(2014)
95 Speciation with gene flow in equids despite extensive chromosomal plasticity
Jónsson H.; Schubert M.; Seguin-Orlando A.; Ginolhac A.; Petersen L.; Fumagalli M.; Albrechtsen A.; Petersen B.; Korneliussen T.S.; Vilstrup J.T.; Lear T.; Myka J.L.; Lundquist J.; Miller D.C.; Alfarhan A.H.; Alquraishi S.A.; Al-Rasheid K.A.S.; Stagegaard J.; Strauss G.; Bertelsen M.F.; Sicheritz-Ponten T.; Antczak D.F.; Bailey E.; Nielsen R.; Willerslev E.; Orlando L.
PNAS(2014)
96 ANGSD: Analysis of Next Generation Sequencing Data
Korneliussen T.S.; Albrechtsen A.; Nielsen R.
BMC Bioinformatics(2014)
97 RelateAdmix: A software tool for estimating relatedness between admixed individuals
Moltke I.; Albrechtsen A.
Bioinformatics(2014)
98 Upper palaeolithic Siberian genome reveals dual ancestry of native Americans
Raghavan M.; Skoglund P.; Graf K.E.; Metspalu M.; Albrechtsen A.; Moltke I.; Rasmussen S.; Stafford T.W., Jr.; Orlando L.; Metspalu E.; Karmin M.; Tambets K.; Rootsi S.; Mägi R.; Campos P.F.; Balanovska E.; Balanovsky O.; Khusnutdinova E.; Litvinov S.; Osipova L.P.; Fedorova S.A.; Voevoda M.I.; Degiorgio M.; Sicheritz-Ponten T.; Brunak Sø.; Demeshchenko S.; Kivisild T.; Villems R.; Nielsen R.; Jakobsson M.; Willerslev E.
Nature(2014)
99 Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil
Malaspinas A.-S.; Lao O.; Schroeder H.; Rasmussen M.; Raghavan M.; Moltke I.; Campos P.F.; Sagredo F.S.; Rasmussen S.; Gonçalves V.F.; Albrechtsen A.; Allentoft M.E.; Johnson P.L.F.; Li M.; Reis S.; Bernardo D.V.; Degiorgio M.; Duggan A.T.; Bastos M.; Wang Y.; Stenderup J.; Moreno-Mayar J.V.; Brunak Sø.; Sicheritz-Ponten T.; Hodges E.; Hannon G.J.; Orlando L.; Price T.D.; Jensen J.D.; Nielsen R.; Heinemeier J.; Olsen J.; Rodrigues-Carvalho C.; Lahr M.M.; Neves W.A.; Kayser M.; Higham T.; Stoneking M.; Pena S.D.J.; Willerslev E.
Current Biology(2014)
100 Prehistoric genomes reveal the genetic foundation and cost of horse domestication
Schubert M.; Jónsson H.; Chang D.; Der Sarkissian C.; Ermini L.; Ginolhac A.; Albrechtsen A. … Nielsen R.; Excoffier L.; Willerslev E.; Shapiro B.; Orlando L.
PNAS(2014)
101 Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis
Laursen J.H.; Søndergaard H.B.; Albrechtsen A.; Frikke-Schmidt R.; Koch-Henriksen N.; Soelberg Sørensen P.; Sellebjerg F.; Oturai A.
Multiple Sclerosis(2014)
102 Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population
Li S.; Besenbacher S.; Li Y.; Kristiansen K.; Grarup N.; Albrechtsen A.; Sparsø T.; Korneliussen T.; Hansen T.; Wang J.; Nielsen R.; Pedersen O.; Bolund L.; Schierup M.H.
EJHG(2014)
103 The genome of a Late Pleistocene human from a Clovis burial site in western Montana
Rasmussen M.; Anzick S.L.; Waters M.R.; Skoglund P.; Degiorgio M.; Stafford Jr. T.W.; Rasmussen S.; Moltke I.; Albrechtsen A.; Doyle S.M.; Poznik G.D.; Gudmundsdottir V.; Yadav R.; Malaspinas A.-S.; Samuel Stockton White V.; Allentoft M.E.; Cornejo O.E.; Tambets K.; Eriksson A.; Heintzman P.D.; Karmin M.; Korneliussen T.S.; Meltzer D.J.; Pierre T.L.; Stenderup J.; Saag L.; Warmuth V.M.; Lopes M.C.; Malhi R.S.; Brunak Sø.; Sicheritz-Ponten T.; Barnes I.; Collins M.; Orlando L.; Balloux F.; Manica A.; Gupta R.; Metspalu M.; Bustamante C.D.; Jakobsson M.; Nielsen R.; Willerslev E.
Nature(2014)
104 A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Moltke I.; Grarup N.; Jørgensen M.E.; Bjerregaard P.; Treebak J.T.; Fumagalli M.; Korneliussen T.S.; Andersen M.A.; Nielsen T.S.; Krarup N.T.; Gjesing A.P.; Zierath J.R.; Linneberg A.; Wu X.; Sun G.; Jin X.; Al-Aama J.; Wang J.; Borch-Johnsen K.; Pedersen O.; Nielsen R.📨; Albrechtsen A.📨; Hansen T.📨
Nature(2014)
105 Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort
Larsen M.H.; Albrechtsen A.; Thørner L.W.; Werge T.; Hansen T.; Gether U.; Haastrup E.; Ullum H.
PLoS ONE(2013)
106 Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Albrechtsen A.; Grarup N.; Li Y.; Sparsø T.; Tian G.; Cao H.; Jiang T.; Kim S.Y.; Korneliussen T.; Li Q.; Nie C.; Wu R.; Skotte L.; Morris A.P.; Ladenvall C.; Cauchi S.; Stančáková A.; Andersen G.; Astrup A.; Banasik K.; Bennett A.J.; Bolund L.; Charpentier G.; Chen Y.; Dekker J.M.; Doney A.S.F.; Dorkhan M.; Forsen T.; Frayling T.M.; Groves C.J.; Gui Y.; Hallmans G.; Hattersley A.T.; He K.; Hitman G.A.; Holmkvist J.; Huang S.; Jiang H.; Jin X.; Justesen J.M.; Kristiansen K.; Kuusisto J.; Lajer M.; Lantieri O.; Li W.; Liang H.; Liao Q.; Liu X.; Ma T.; Ma X.; Manijak M.P.; Marre M.; Mokrosiński J.; Morris A.D.; Mu B.; Nielsen A.A.; Nijpels G.; Nilsson P.; Palmer C.N.A.; Rayner N.W.; Renström F.; Ribel-Madsen R.; Robertson N.; Rolandsson O.; Rossing P.; Schwartz T.W.; Slagboom P.E.; Sterner M.; Tang M.; Tarnow L.; Tuomi T.; Van’T Riet E.; Van Leeuwen N.; Varga T.V.; Vestmar M.A.; Walker M.; Wang B.; Wang Y.; Wu H.; Xi F.; Yengo L.; Yu C.; Zhang X.; Zhang J.; Zhang Q.; Zhang W.; Zheng H.; Zhou Y.; Altshuler D.; ‘T Hart L.M.; Franks P.W.; Balkau B.; Froguel P.; McCarthy M.I.; Laakso M.; Groop L.; Christensen C.; Brandslund I.; Lauritzen T.; Witte D.R.; Linneberg A.; Jørgensen T.; Hansen T.; Wang J.; Nielsen R.; Pedersen O.
Diabetologia(2013)
107 Estimating inbreeding coefficients from NGS data: Impact on genotype calling and allele frequency estimation
Vieira F.G.; Fumagalli M.; Albrechtsen A.; Nielsen R.
Genome Research(2013)
108 Recalibrating equus evolution using the genome sequence of an early Middle Pleistocene horse
Orlando L.; Ginolhac A.; Zhang G.; Froese D.; Albrechtsen A.; Stiller M.; Schubert M.; Cappellini E.; Petersen B.; Moltke I.; Johnson P.L.F.; Fumagalli M.; Vilstrup J.T.; Raghavan M.; Korneliussen T.; Malaspinas A.-S.; Vogt J.; Szklarczyk D.; Kelstrup C.D.; Vinther J.; Dolocan A.; Stenderup J.; Velazquez A.M.V.; Cahill J.; Rasmussen M.; Wang X.; Min J.; Zazula G.D.; Seguin-Orlando A.; Mortensen C.; Magnussen K.; Thompson J.F.; Weinstock J.; Gregersen K.; Røed K.H.; Eisenmann V.; Rubin C.J.; Miller D.C.; Antczak D.F.; Bertelsen M.F.; Brunak Sø.; Al-Rasheid K.A.S.; Ryder O.; Andersson L.; Mundy J.; Krogh A.; Gilbert M.T.P.; Kjær K.; Sicheritz-Ponten T.; Jensen L.J.; Olsen J.V.; Hofreiter M.; Nielsen R.; Shapiro B.; Wang J.; Willerslev E.
Nature(2013)
109 Calculation of Tajima’s D and other neutrality test statistics from low depth next-generation sequencing data
Korneliussen T.S.; Moltke I.; Albrechtsen A.; Nielsen R.
BMC Bioinformatics(2013)
110 Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes
Lohmueller K.E.; Sparsø T.; Li Q.; Andersson E.; Korneliussen T.; Albrechtsen A.; Banasik K.; Grarup N.; Hallgrimsdottir I.; Kiil K.; Kilpeläinen T.O.; Krarup N.T.; Pers T.H.; Sanchez G.; Hu Y.; Degiorgio M.; Jørgensen T.; Sandbæk A.; Lauritzen T.; Brunak Sø.; Kristiansen K.; Li Y.; Hansen T.; Wang J.; Nielsen R.; Pedersen O.
AJHG(2013)
111 Genetic Architecture of Vitamin B12 and Folate Levels Uncovered Applying Deeply Sequenced Large Datasets
Grarup N.; Sulem P.; Sandholt C.H.; Thorleifsson G.; Ahluwalia T.S.; Steinthorsdottir V.; Bjarnason H.; Gudbjartsson D.F.; Magnusson O.T.; Sparsø T.; Albrechtsen A.; Kong A.; Masson G.; Tian G.; Cao H.; Nie C.; Kristiansen K.; Husemoen L.L.; Thuesen B.; Li Y.; Nielsen R.; Linneberg A.; Olafsson I.; Eyjolfsson G.I.; Jørgensen T.; Wang J.; Hansen T.; Thorsteinsdottir U.; Stefánsson K.; Pedersen O.
PLoS Genetics(2013)
112 Quantifying population genetic differentiation from next-generation sequencing data
Fumagalli M.; Vieira F.G.; Korneliussen T.S.; Linderoth T.; Huerta-Sánchez E.; Albrechtsen A.; Nielsen R.
Genetics(2013)
113 Estimating individual admixture proportions from next generation sequencing data
Skotte L.; Korneliussen T.S.; Albrechtsen A.
Genetics(2013)
114 SNP calling, genotype calling, and sample allele frequency estimation from new-generation sequencing data
Nielsen R.; Korneliussen T.; Albrechtsen A.; Li Y.; Wang J.
PLoS ONE(2012)
115 Association Testing for Next-Generation Sequencing Data Using Score Statistics
Skotte L.; Korneliussen T.S.; Albrechtsen A.
Genetic Epidemiology(2012)
116 Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome
Lohmueller K.E.; Albrechtsen A.; Li Y.; Kim S.Y.; Korneliussen T.; Vinckenbosch N.; Tian G.; Huerta-Sanchez E.; Feder A.F.; Grarup N.; Jørgensen T.; Jiang T.; Witte D.R.; Sandbæk A.; Hellmann I.; Lauritzen T.; Hansen T.; Pedersen O.; Wang J.; Nielsen R.
PLoS Genetics(2011)
117 A method for detecting IBD regions simultaneously in multiple individuals - With applications to disease genetics
Moltke I.; Albrechtsen A.; Hansen T.V.O.; Nielsen F.C.; Nielsen R.
Genome Research(2011)
118 An aboriginal Australian genome reveals separate human dispersals into Asia
Rasmussen M.; Guo X.; Wang Y.; Lohmueller K.E.; Rasmussen S.; Albrechtsen A.; Skotte L.; Lindgreen S.; Metspalu M.; Jombart T.; Kivisild T.; Zhai W.; Eriksson A.; Manica A.; Orlando L.; De La Vega F.M.; Tridico S.; Metspalu E.; Nielsen K.; Ávila-Arcos M.C.; Víctor Moreno-Mayar J.; Muller C.; Dortch J.; Gilbert M.T.P.; Lund O.; Wesolowska A.; Karmin M.; Weinert L.A.; Wang B.; Li J.; Tai S.; Xiao F.; Hanihara T.; Van Driem G.; Jha A.R.; Ricaut F.-X.; De Knijff P.; Migliano A.B.; Romero I.G.; Kristiansen K.; Lambert D.M.; Brunak S.; Forster P.; Brinkmann B.; Nehlich O.; Bunce M.; Richards M.; Gupta R.; Bustamante C.D.; Krogh A.; Foley R.A.; Lahr M.M.; Balloux F.; Sicheritz-Pontén T.; Villems R.; Nielsen R.; Wang J.; Willerslev E.
Science(2011)
119 Estimation of allele frequency and association mapping using next-generation sequencing data
Kim S.Y.; Lohmueller K.E.; Albrechtsen A.; Li Y.; Korneliussen T.; Tian G.; Grarup N.; Jiang T.; Andersen G.; Witte D.; Jorgensen T.; Hansen T.; Pedersen O.; Wang J.; Nielsen R.
BMC Bioinformatics(2011)
120 Genotype and SNP calling from next-generation sequencing data
Nielsen R.; Paul J.S.; Albrechtsen A.; Song Y.S.
Nature Reviews Genetics(2011)
121 Ancient human genome sequence of an extinct Palaeo-Eskimo
Rasmussen M.; Li Y.; Lindgreen S.; Pedersen J.S.; Albrechtsen A.; Moltke I.; Metspalu M.; Metspalu E.; Kivisild T.; Gupta R.; Bertalan M.; Nielsen K.; Gilbert M.T.P.; Wang Y.; Raghavan M.; Campos P.F.; Kamp H.M.; Wilson A.S.; Gledhill A.; Tridico S.; Bunce M.; Lorenzen E.D.; Binladen J.; Guo X.; Zhao J.; Zhang X.; Zhang H.; Li Z.; Chen M.; Orlando L.; Kristiansen K.; Bak M.; Tommerup N.; Bendixen C.; Pierre T.L.; Gronnow B.; Meldgaard M.; Andreasen C.; Fedorova S.A.; Osipova L.P.; Higham T.F.G.; Ramsey C.B.; Hansen T.V.O.; Nielsen F.C.; Crawford M.H.; Brunak S.; Sicheritz-Pont́n T.; Villems R.; Nielsen R.; Krogh A.; Wang J.; Willerslev E.
Nature(2010)
122 Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
Gjesing A.P.; Larsen L.H.; Torekov S.S.; Hainerová I.A.; Kapur R.; Johansen A.; Albrechtsen A.; Boj S.; Holst B.; Harper A.; Urhammer S.A.; Borch-Johnsen K.; Pisinger C.; Echwald S.M.; Eiberg H.; Astrup A.; Lebl J.; Ferrer J.; Schwartz T.W.; Hansen T.; Pedersen O.
PLoS ONE(2010)
123 Ascertainment biases in SNP chips affect measures of population divergence
Albrechtsen A.; Nielsen F.C.; Nielsen R.
Mol Biol Evol(2010)
124 Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: Implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer
Hansen T.V.O.; Jønson L.; Albrechtsen A.; Steffensen A.Y.; Bergsten E.; Myrhøj T.; Ejlertsen B.; Nielsen F.C.
Breast Cancer Res Treat(2010)
125 Natural selection and the distribution of identity-by-descent in the human genome
Albrechtsen A.; Moltke I.; Nielsen R.
Genetics(2010)
126 Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes
Fosgerau K.; Galle P.; Hansen T.; Albrechtsen A.; De Lemos Rieper C.; Pedersen B.K.; Larsen L.K.; Thomsen A.R.; Pedersen O.; Hansen M.B.; Steensberg A.
Journal of Endocrinology(2010)
127 Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
Li Y.; Vinckenbosch N.; Tian G.; Huerta-Sanchez E.; Jiang T.; Jiang H.; Albrechtsen A.; Andersen G.; Cao H.; Korneliussen T.; Grarup N.; Guo Y.; Hellman I.; Jin X.; Li Q.; Liu J.; Liu X.; Sparsø T.; Tang M.; Wu H.; Wu R.; Yu C.; Zheng H.; Astrup A.; Bolund L.; Holmkvist J.; Jørgensen T.; Kristiansen K.; Schmitz O.; Schwartz T.W.; Zhang X.; Li R.; Yang H.; Wang J.; Hansen T.; Pedersen O.; Nielsen R.; Wang J.
Nature Genetics(2010)
128 Segregation distortion in chicken and the evolutionary consequences of female meiotic drive in birds
Axelsson E.; Albrechtsen A.; Van A.P.; Li L.; Megens H.J.; Vereijken A.L.J.; Crooijmans R.P.M.A.; Groenen M.A.M.; Ellegren H.; Willerslev E.; Nielsen R.
Heredity(2010)
129 Identification of a novel locus for a USH3 like syndrome combined with congenital cataract
Dad S.; Østergaard E.; Thykjær T.; Albrectsen A.; Ravn K.; Rosenberg T.; Møller L.B.
Clinical Genetics(2010)
130 Combined analyses of 20 common obesity susceptibility variants
Sandholt C.H.; Sparsø T.; Grarup N.; Albrechtsen A.; Almind K.; Hansen L.; Toft U.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetes(2010)
131 Darwinian and demographic forces affecting human protein coding genes
Nielsen R.; Hubisz M.J.; Hellmann I.; Torgerson D.; Andrés A.M.; Albrechtsen A.; Gutenkunst R.; Adams M.D.; Cargill M.; Boyko A.; Indap A.; Bustamante C.D.; Clark A.G.
Genome Research(2009)
132 Functional SOCS1 polymorphisms are associated with variation in obesity in whites
Gylvin T.; Ek J.; Nolsøe R.; Albrechtsen A.; Andersen G.; Bergholdt R.; Brorsson C.; Bang-Berthelsen C.H.; Hansen T.; Karlsen A.E.; Billestrup N.; Borch-Johnsen K.; Jørgensen T.; Pedersen O.; Mandrup-Poulsen T.; Nerup J.; Pociot F.
Diabetes Obes Metab(2009)
133 The validation and assessment of machine learning: A game of prediction from high-dimensional data
Pers T.H.; Albrechtsen A.; Holst C.; Sørensen T.I.A.; Gerds T.A.
PLoS ONE(2009)
134 Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
Sparsø T.; Grarup N.; Andreasen C.; Albrechtsen A.; Holmkvist J.; Andersen G.; Jørgensen T.; Borch-Johnsen K.; Sandbæk A.; Lauritzen T.; Madsbad S.; Hansen T.; Pedersen O.
Diabetologia(2009)
135 A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
Rose C.S.; Grarup N.; Krarup N.T.; Poulsen P.; Wegner L.; Nielsen T.; Banasik K.; Færch K.; Andersen G.; Albrechtsen A.; Borch-Johnsen K.; Clausen J.O.; Jørgensen T.; Vaag A.; Pedersen O.; Hansen T.
Diabetologia(2009)
136 Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families
Hansen T.V.O.; Jønson L.; Albrechtsen A.; Andersen M.K.; Ejlertsen B.; Nielsen F.C.
Breast Cancer Res Treat(2009)
137 Relatedness mapping and tracts of relatedness for genome-wide data in the presence of linkage disequilibrium
Albrechtsen A.; Korneliussen T.S.; Moltke I.; van Overseem Hansen T.; Nielsen F.C.; Nielsen R.
Genetic Epidemiology(2009)
138 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Rung J.; Cauchi S.; Albrechtsen A.*; Shen L.; Rocheleau G.; Cavalcanti-Proença C.; Bacot F.; Balkau B.; Belisle A.; Borch-Johnsen K.; Charpentier G.; Dina C.; Durand E.; Elliott P.; Hadjadj S.; Järvelin M.-R.; Laitinen J.; Lauritzen T.; Marre M.; Mazur A.; Meyre D.; Montpetit A.; Pisinger C.; Posner B.; Poulsen P.; Pouta A.; Prentki M.; Ribel-Madsen R.; Ruokonen A.; Sandbaek A.; Serre D.; Tichet J.; Vaxillaire M.; Wojtaszewski J.F.P.; Vaag A.; Hansen T.; Polychronakos C.; Pedersen O.; Froguel P.; Sladek R.
Nature Genetics(2009)
139 A common Greenlandic Inuit BRCA1 RING domain founder mutation
Hansen T.V.O.; Ejlertsen B.; Albrechtsen A.; Bergsten E.; Bjerregaard P.; Hansen T.; Myrhøj T.; Nielsen P.B.; Timmermans-Wielenga V.; Andersen M.K.; Jønson L.; Nielsen F.C.
Breast Cancer Res Treat(2009)
140 The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
Grarup N.; Andreasen C.H.; Andersen M.K.; Albrechtsen A.; Sandbæk A.; Lauritzen T.; Borch-Johnsen K.; Jørgensen T.; Schmitz O.; Hansen T.; Pedersen O.
J Clin Endocrinol Metab(2008)
141 The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes
Sparsø T.; Andersen G.; Nielsen T.; Burgdorf K.S.; Gjesing A.P.; Nielsen A.L.; Albrechtsen A.; Rasmussen S.S.; Jørgensen T.; Borch-Johnsen K.; Sandbæk A.; Lauritzen T.; Madsbad S.; Hansen T.; Pedersen O.
Diabetologia(2008)
142 Novel de novo BRCA2 mutation in a patient with a family history of breast cancer
Hansen T.V.O.; Bisgaard M.L.; Jønson L.; Albrechtsen A.; Filtenborg-Barnkob B.; Eiberg H.; Ejlertsen B.; Nielsen F.C.
BMC Medical Genetics(2008)
143 Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
Andreasen C.H.; Stender-Petersen K.L.; Mogensen M.S.; Torekov S.S.; Wegner L.; Andersen G.; Nielsen A.L.; Albrechtsen A.; Borch-Johnsen K.; Rasmussen S.S.; Clausen J.O.; Sandbæk A.; Lauritzen T.; Hansen L.; Jørgensen T.; Pedersen O.; Hansen T.
Diabetes(2008)
144 Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged danes
Grarup N.; Andersen G.; Krarup N.T.; Albrechtsen A.; Schmitz O.; Joørgensen T.; Borch-Johnsen K.; Hansen T.; Pedersen O.
Diabetes(2008)
145 Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
Sparsø T.; Andersen G.; Albrechtsen A.; Jørgensen T.; Borch-Johnsen K.; Sandbæk A.; Lauritzen T.; Wasson J.; Permutt M.A.; Glaser B.; Madsbad S.; Pedersen O.; Hansen T.
Diabetologia(2008)
146 Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects
Grarup N.; Andersen M.K.; Andreasen C.H.; Albrechtsen A.; Borch-Johnsen K.; Jørgensen T.; Auwerx J.; Schmitz O.; Hansen T.; Pedersen O.
J Clin Endocrinol Metab(2007)
147 A -243A→G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged white subjects
Boesgaard T.W.; Castella S.I.; Andersen G.; Albrechtsen A.; Sparsø T.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetic Medicine(2007)
148 A bayesian multilocus association method: Allowing for higher-order interaction in association studies
Albrechtsen A.; Castella S.; Andersen G.; Hansen T.; Pedersen O.; Nielsen R.
Genetics(2007)
149 Genetic analysis of the estrogen-related receptor α and studies of association with obesity and type 2 diabetes
Larsen L.H.; Rose C.S.; Sparsø T.; Overgaard J.; Torekov S.S.; Grarup N.; Jensen D.P.; Albrechtsen A.; Andersen G.; Ek J.; Glümer C.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Int J Obes(2007)
150 Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: Validation and extension of genome-wide association studies
Grarup N.; Rose C.S.; Andersson E.A.; Andersen G.; Nielsen A.L.; Albrechtsen A.; Clausen J.O.; Rasmussen S.S.; Jørgensen T.; Sandbæk A.; Lauritzen T.; Schmitz O.; Hansen T.; Pedersen O.
Diabetes(2007)
151 Studies of associations between the Arg389Gly polymorphism of the β1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects
Gjesing A.P.; Andersen G.; Albrechtsen A.; Glümer C.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetic Medicine(2007)
152 Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people
Grarup N.; Albrechtsen A.; Ek J.; Borch-Johnsen K.; Jørgensen T.; Schmitz O.; Hansen T.; Pedersen O.
Diabetologia(2007)
153 A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4α gene (HNF4A) associates with late-onset diabetes
Ek J.; Hansen S.P.; Lajer M.; Nicot C.; Boesgaard T.W.; Pruhova S.; Johansen A.; Albrechtsen A.; Yderstræde K.; Lauenborg J.; Parrizas M.; Boj S.F.; Jørgensen T.; Borch-Johnsen K.; Damm P.; Ferrer J.; Lebl J.; Pedersen O.; Hansen T.
Diabetes(2006)
154 Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes
Wegner L.; Andersen G.; Albrechtsen A.; Sparsø T.; Glümer C.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetic Medicine(2006)
155 Variants in the 5′ region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects
Torekov S.S.; Larsen L.H.; Andersen G.; Albrechtsen A.; Glümer C.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetologia(2006)
156 Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects
Grarup N.; Urhammer S.A.; Ek J.; Albrechtsen A.; Glümer C.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetologia(2006)
157 Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes
Andersen G.; Overgaard J.; Albrechtsen A.; Glümer C.; Borch-Johnsen K.; Jørgensen T.; Hansen T.; Pedersen O.
Diabetologia(2006)